HTLV-1 SPECIFIC CD8+ T CELL FUNCTION AUGMENTED BY BLOCKADE OF 2B4/CD48 INTERACTION IN HTLV-1 INFECTION.




The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds to activated and infected brain macrophages in areas of synaptic degeneration: Implications for PET imaging of neuroinflammation in lentiviral encephalitis

HIV encephalitis (HIVE) is characterized by neurodegeneration mediated by toxins derived from infected and activated brain macrophages.Since the peripheral benzodiazepine receptor (PBR) is abundant on brain macrophages, we hypothesized that [3H]DAA1106, a new PBR ligand, can label infected and activated brain macrophages in HIVE.Using cell culture

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A Spectroscopic Technique to Simultaneously Characterize Fatty Acid Uptake, Mitochondrial Activity, Vascularity, and Oxygen Saturation for Longitudinal Studies In Vivo

Aggressive breast cancer has been shown to shift its metabolism towards increased lipid catabolism as the primary carbon source for oxidative phosphorylation.In this study, we present a technique to longitudinally monitor lipid metabolism and oxidative phosphorylation in pre-clinical tumor models to investigate the metabolic changes with mammary ti

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